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Functional neurogenesis in the adult hippocampus

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    Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Nature , 01 Feb , : DOI: Read article at publisher's site DOI : Neural Regen Res , 15 1 , 01 Jan Neurobiol Stress , , 20 Dec
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    Neurogenesis in the Adult Hippocampus

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    Functional neurogenesis in the adult hippocampus. - Abstract - Europe PMC

    Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. A Nature Research Journal. There is extensive evidence indicating that new neurons are generated in the dentate gyrus of the adult mammalian hippocampus, a region of the brain that is important for learning and memory 1 , 2 , 3 , 4 , 5. However, it is not known whether these new neurons become functional, as the methods used to study adult neurogenesis are limited to fixed tissue.
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    Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates

    Of the neurogenic zones in the adult brain, adult hippocampal neurogenesis attracts the most attention, because it is involved in higher cognitive function, most notably memory processes, and certain affective behaviors. Adult hippocampal neurogenesis is also found in humans at a considerable level and appears to contribute significantly to hippocampal plasticity across the life span, because it is regulated by activity. Adult hippocampal neurogenesis generates new excitatory granule cells in the dentate gyrus, whose axons form the mossy fiber tract that links the dentate gyrus to CA3.
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    Adult neurogenesis twenty years later: physiological function versus brain repair View all 19 Articles. The finding that new neurons are born and become integrated into a mature circuitry throughout life has challenged and subsequently reshaped our understanding of neural plasticity in the adult mammalian brain. It is now widely accepted that neurogenesis in the adult central nervous system occurs in multiple brain regions within the rodent brain, including the subventricular zone SVZ of the lateral ventricles and the subgranular zone SGZ of the dentate gyrus DG. Since the discovery of ongoing neurogenesis in the adult brain, the field has been addressing questions regarding the cellular identity of adult NSPCs, the molecular pathways regulating maturation and integration of newborn neurons into preexisting circuitries, and how new neurons contribute to adult brain function.
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